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Aims: Examine healthcare costs across chronic kidney disease (CKD) stages for US patients with type 2 diabetes (T2D).

Materials and methods: IQVIA Real World Data Adjudicated Claims linked electronic medical records and insurance claims from January 1, 2012 through March 31, 2017 were used for this retrospective study. Adults diagnosed with T2D and comorbid CKD were included. General linear models incorporating splines were constructed, and information from these regressions were used to inform the relationship between medical costs and CKD. Multivariable analyses controlled for patient characteristics, vital signs, general health, prior medication use, prior visit to specialists, index A1c, and year of index date.

Results: There were 6,645 individuals who met the study criteria. Results generally indicate sharp increases in annual total medical costs and non-drug medical costs in the 1?year post-period for patients with Stage 4 or 5 CKD (estimated glomerular filtration rate [eGFR]?≤?30?mL/min/1.73 m2) with each 1 point reduction in eGFR from 30 associated with an increase of $1,870 in all-cause total medical costs (p?<?0.0001) and $1,805 of all-cause non-drug medical costs (p?<?0.0001). Similarly, each point decline below 30?mL/min was associated annual cost increases of $1,701 for CKD-related total medical costs, $1,695 for CKD-related non-drug medical costs, $173 for diabetes-related medical costs, and $187 for diabetes-related non-drug medical costs (all p?<?0.0001).

Limitations: The investigation included only patients with medical insurance and laboratory test results, and results may not be generalizable to all T2D patients with CKD. The methodology allowed us to determine associations, not causation, and potential confounders, such as duration of diabetes, diet, exercise, or social support, could not be assessed.

Conclusions: Results indicate there are sharp and significant increases in medical costs among T2D patients with Stage 4 and 5 CKD compared to those with earlier stages of CKD.  相似文献   
13.
This paper explores small and medium enterprises’ (SMEs) proximity preferences when selecting partners for collaborative process innovation. Drawing on a survey of 362 Danish SMEs, we address four partner proximity characteristics: geographic, cognitive, organizational, and social. The results show that SMEs prioritize geographic openness over regional clustering. Furthermore, to simultaneously facilitate collaboration and ensure innovation, firms tend to collaborate with partners that are characterized by cognitive similarity at a technological level and knowledge distance at a market level. Technological proximity is also found to be more relevant than social proximity when it comes to bridging the potential geographic and market distance between the collaborative partners. Finally, the results indicate that the tendency of organizational proximity to facilitate informal interactions with partners enhances process innovation only at two of four process innovation levels. Thus, the results highlight the fact that the value of partner proximity characteristics change with the level of process innovation considered.  相似文献   
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In past years, beekeeping as an agricultural sector has become more organized, but there is still a gap in knowledge in considering consumer preferences for honey. The aim of the research was to determine consumer preferences for honey and their attitudes towards the Protected Designation of Origin (PDO) label. Also, in the article is presented the current situation regarding the honey market and legislation of the PDO label at the EU and national levels. The result of the empirical research carried out on a sample of 1008 respondents showed that they mostly prefer a mild flavour and brighter colour of honey. According to the type, most of the respondents prefer acacia rather than floral and meadow honeys or other types of honey. The most common method of honey purchase is directly from the producers (75%). The results of the Principle Component Analysis (PCA) showed that the most important attributes are the intrinsic attributes of the honey and that the most common reasons for purchasing and consuming honey are for its health and medical benefits. The obtained results fill the gap in knowledge regarding consumer preferences for honey in the Croatian market and can be useful for the creation of new honey-marketing strategies for local beekeepers.  相似文献   
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Political targets for implementing the German “energy turnaround” aiming at the ambitious extension of renewable energies to generate electricity. However, a majority of the renewable supply is provided by intermittent sources, e.g. wind and solar power. For balancing the increasing supply fluctuations additional storage options are claimed beside of an enforced grid infrastructure and a more flexible demand side. Despite of the political guidelines the economics of additional flexibility measures has to be considered. For this paper we analyse the costs of large scale stationary battery storages to be operated in wholesale markets and transmission grid level. By deriving a key figure based on a life-cycle cost approach, we are able to evaluate the additional costs of electricity of selected battery technologies (lead-acid, lithium ion, sodium sulphur, redox-flow). Moreover, current and valid parameters of the cost analysis are received by scientific and industrial stakeholders of battery systems via online survey and face-to-face interviews. According to the stakeholder estimation a nationwide operation of stationary battery storages will be established at wholesale and transmission grid level until the year 2030. The life-cycle cost analysis, which also includes estimated future cost reductions, shows that lead-acid batteries remain the cost-efficient technology, assuming about 100 storage cycles p.a. In addition, a sensitivity analysis reveals the impact of increasing annual storage cycles as well as the achievable cost reduction by economies-of-scales of the power unit of the storage system.  相似文献   
16.
We investigate the effect of say‐on‐pay (SOP) proposals on changes in executive and director compensation. Relative to non‐SOP firms, SOP firms’ total compensation to CEOs does not significantly change after the proposal. However, the mix of compensation does change—companies move away from using cash compensation toward more incentive compensation, offsetting the reduction in bonus. Further, the mix of compensation of non‐CEO executives changes similarly to that of CEOs. Compensation to directors of SOP firms increases less than non‐SOP firms. Firms whose CEOs are well compensated, especially with cash‐based compensation, are most likely to receive a proposal.  相似文献   
17.
How best to define performance measures is a much-debated issue. Mismatches between goals and indicators can lead to distortions that undermine impact-oriented steering. This article presents a model of goal and indicator development and explains its applicability, benefits and limitations.  相似文献   
18.
Drawing upon the work of Simmel ([1907–1911] 1971) and other socioculturally oriented theoreticians (e.g. Campbell 1987; Thompson et al. 1994), this paper illuminates the composite and dynamic character of leisure shopping. Using three overarching themes – the adventure, the auction and the aspiration – the paper illustrates that leisure shopping experiences comprise a synthesis of opposites, involving dynamic shifts between for example spontaneity and control, delight and disappointment, dreams and fantasies as well as rational calculations and purposive planning. Leisure shopping is thus described as a form of rational recreation (Lash and Urry 2002), where consumers seek pleasure in highly rationalized ways.  相似文献   
19.
Efforts are being made to examine how the arts help people reach their full potential and contribute to subjective well-being. The purpose of this research is to examine the relationship between artistic consumption and consumer well-being. Specifically, consumer motives, represented as emotion regulation, and arts engagement are examined to assess the relationship between arts participation and life satisfaction. This assessment is carried out in 2 countries, the United States and Croatia. Findings from both countries indicate that emotion regulation is positively related to arts engagement. In turn, arts engagement is positively related to arts participation for consumers in both countries. Results, however, diverge for both countries with respect to the influence that artistic consumption has on global life satisfaction. For U.S. consumers, arts participation is positively related to life satisfaction; yet arts participation is not related to satisfaction for Croatian consumers. Implications for the role the arts play in contributing to consumer well-being are discussed.  相似文献   
20.
This study traces the development of the management accountant (MA) role at the Swedish Social Insurance Agency (SIA). In 2012, the agency began a reformation by implementing the Lean management system in hopes of increasing customer trust. The results of this study show that the authority of the MA rests on decentralization and the proximity of MAs to managers, as previous research has shown, and more specifically on a definitional and a moral prerogative that may or may not be awarded to MAs enabling them to act as de facto managers. The study shows how the role of the SIA's operative level MAs changed into a helpdesk function with the role of assisting other groups to help themselves, in this case operative‐level teams that had begun performing management accounting tasks. Thus, this study bears witness not to the expansion and hybridization of existing MA roles, but to the reduction in authority and de‐hybridization of the MA role, from business partner to a pedagogical role on a consultative basis.  相似文献   
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